ESPN College GameDay is on location in Coral Gables, Florida as one of Notre Dame’s previous opponents, the Miami Hurricanes are hosting the Florida Gators.
It’s not the biggest game of the day, but it’s a huge rivalry game with the two teams going in different directions. The Hurricanes once again are looking like a College Football Playoff team, while the Gators haven struggled to a 1-2 record and there is chatter that the fan base wants head coach Billy Napier fired with eyes on the Irish’s Marcus Freeman.
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Regardless of that, the GameDay crew of Desmond Howard, Nick Saban, Pat McAfee and Kirk Herbstreit were joined by NHL star Matthew Tkachuk, son of great Keith, who’s Florida Panthers have won the last two Stanley Cups. They picked the top games across college football in Week 4, and you can find out below who they think will win.
Syracuse Orange at Clemson Tigers
Sep 6, 2025; Syracuse, New York, USA; Syracuse Orange quarterback Steve Angeli (9) throws against the UConn Huskies during the second half at JMA Wireless Dome. Mandatory Credit: Gregory Fisher-Imagn Images
Howard – Syracuse
Saban – Syracuse
Tkachuk – Syracuse
McAfee – Syracuse
Herbstreit – Clemson
South Carolina Gamecocks at No. 23 Missouri Tigers
Sep 13, 2025; Columbia, South Carolina, USA; South Carolina Gamecocks head coach Shane Beamer walks off the field following their loss to the Vanderbilt Commodores at Williams-Brice Stadium. Mandatory Credit: Jeff Blake-Imagn Images
Howard – South Carolina
Saban – Missouri
Tkachuk – Missouri
McAfee – South Carolina
Herbstreit – South Carolina
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Sep 6, 2025; Tallahassee, Florida, USA; Florida State Seminoles wide receiver Micahi Danzy (19) reacts as he scores a touchdown during the second half against the East Texas A&M Lions at Doak S. Campbell Stadium. Mandatory Credit: Melina Myers-Imagn Images
Howard – Kent State (spread pick)
Saban – Florida State
Tkachuk – Florida State
McAfee – Florida State
Herbstreit – Florida State
No. 22 Auburn Tigers at No. 11 Oklahoma Sooners
Sep 13, 2025; Philadelphia, Pennsylvania, USA; Oklahoma Sooners defensive lineman Jacob Henry (92) poses after the game against the Temple Owls at Lincoln Financial Field. Mandatory Credit: Kyle Ross-Imagn Images
Howard – Auburn
Saban – Oklahoma
Tkachuk – Oklahoma
McAfee – Oklahoma
Herbstreit – Oklahoma
SMU Mustangs at TCU Horned Frogs
Sep 1, 2025; Chapel Hill, North Carolina, USA; TCU Horned Frogs players celebrate after the game at Kenan Stadium. Mandatory Credit: Bob Donnan-Imagn Images
Howard – TCU
Saban – TCU
Tkachuk – TCU
McAfee – TCU
Herbstreit – TCU
No. 9 Illinois Fighting Illini at No. 19 Indiana Hoosiers
Sep 13, 2025; Champaign, Illinois, USA; Illinois Fighting Illini defensive lineman James Thompson Jr. celebrates a 38-0 win against the Western Michigan Broncos at Memorial Stadium. Mandatory Credit: Ron Johnson-Imagn Images
Howard – Illinois
Saban – Illinois
Tkachuk – Illinois
McAfee – Indiana
Herbstreit – Illinois
No. 17 Texas Tech Red Raiders at No. 16 Utah Utes
Sep 13, 2025; Laramie, Wyoming, USA; Utah Utes tight end JJ Buchanan (81) celebrates his touchdown reception with tight end Hunter Andrews (10) in the fourth quarter against the Wyoming Cowboys at Jonah Field at War Memorial Stadium. Mandatory Credit: Ron Chenoy-Imagn Images
Howard – Utah
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Saban – Utah
Tkachuk – Utah
McAfee – Utah
Herbstreit – Utah
No. 21 Michigan Wolverines at Nebraska Cornhuskers
Sep 13, 2025; Ann Arbor, Michigan, USA; Michigan Wolverines defensive back Brandyn Hillman (6) and linebacker Ernest Hausmann (15) celebrate a play in the first half against the Central Michigan Chippewas at Michigan Stadium. Mandatory Credit: Rick Osentoski-Imagn Images
Howard – Michigan
Saban – Michigan
Tkachuk – Michigan
McAfee – Nebraska
Herbstreit – Michigan
Sep 13, 2025; Miami Gardens, Florida, USA; Miami Hurricanes quarterback Carson Beck (11) reacts on the field against the South Florida Bulls during the fourth quarter at Hard Rock Stadium. Mandatory Credit: Sam Navarro-Imagn Images
Howard – Miami
Saban – Miami
Tkachuk – Miami
McAfee – Miami
Herbstreit – no pick
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This article originally appeared on Fighting Irish Wire: ESPN College GameDay picks the winners of Week 4 in college football
